![]() All these compounds were examined for cytotoxic and antimicrobial activities. The structures of these compounds were determined by detailed analysis of the NMR and mass spectrometric data and compounds 1 and 3 were confirmed by single-crystal X-ray diffraction analysis. Further work on the remaining fractions of the fungus resulted in the isolation of five new sulfide diketopiperazine derivatives, namely, penicibrocazines A–E ( 1– 5) and one known analog ( 6) ( Figure 1). Very recently, six new cytotoxic bisthiodiketopiperazine derivatives, brocazines A–F, have been isolated from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. ![]() As part of our recently initiated program aimed at the discovery of bioactive secondary metabolites from marine-derived fungi, a series of structurally interesting and biologically active natural products has been described. Pixi Beauty awesomefeed skintreats cleanser hide-notify-btn nothellokitty skintreats under-25 whats new add-to-cart ///s/files/1/1463/5858/products/Pixi2846_edit.jpg?v=1605825643 5260540870688 Default Title 18.00 ///shopifycloud/shopify/assets/no-image-2048-5e88c1b20e087fb7bbe9a3771824e743c244f437e4f8ba93bbf7b11b53f7824c.Thiodiketopiperazine derivatives, which generally possess a 6-5-6-5-6 diketopiperazine skeleton with a disulfide bridge or S-methyl group(s), have attracted considerable attention due to their diversified structures and potent biological activities.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |